Multiple in vitro studies have demonstrated that NAC actively induces the non-immunological degranulation of mast cells, causing them to dump pre-formed histamine directly into the bloodstream, which can trigger immediate allergic-type symptoms
This supports topical efficacy on dermal structures, including fibroblasts
Research Highlights Enhanced wound healing: Stimulates collagen, elastin, and other ECM components in vitro and in vivo 1,4
But it also regulates the immune response, for example in the production of cytokinesCytokines are small proteins produced by the immune system, which bind to specific receptors present on the cell membrane and communicate to the cell a specific set of instructions such as, for example, the stimulus to grow, or to differentiate or even the order to die