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Death was determined based on standardized criteria including the absence of respiration, absence of heartbeat, loss of pupillary light reflex, and absence of reflexes, with scavenging and operator protection measures in place

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The transdermal composition of claim 2 which provides at least one of the following release pattern in an In Vitro study employing dialysis membrane and a phosphate buffer of pH 7.4 i) at least 30 % release in 24 hrs and 70 % release in 72 hrs

It is critical to note that the safety profile for injectable or systemic use is far less established due to a lack of human research