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Initial unbiased enrichment analysis highlighted activation of cell cycle, DNA replication and repair, and metabolism -related pathways (Supplementary Tables S8-10)

Immunohistochemical staining for Nrf2, NQO1, and HO-1 expression on knee joint histological sections demonstrated that metformin administration significantly increased the numbers of Nrf2, NQO1, and HO-1-positive chondrocytes compared to those in OA group (Fig

The typical dosing range spans from 2.5 mg weekly at the starting level up to 15 mg weekly as a maximum maintenance dose

Meurot C, Jacques C, Martin C, Sudre L, Breton J, Rattenbach R, Bismuth K, Berenbaum F