glp-1 agonist incretin effect GLP-1 Drugs: A Complete History of Incretin-Based Therapy November 2, 2025 Updated March 8, 2026 70 min read Learn the complete history of GLP-1 drugs from the incretin effect to 2026 breakthroughs
New formulations and ongoing studies aim to optimize their use in preventing and treating heart disease
These two nutrients work in a beautiful, circular relationship to protect your cells, support your liver, and keep your immune system ready for anything
GLP-1 RAs Hold Promising Potential for Reduction of Cardiometabolic Risk Factors additional benefits : Brain: Appetite suppression, nerve protection, and decreased neuroinflammation Heart: Decreased blood pressure (systolic and diastolic), reduced total cholesterol levels, lowered endothelial dysfunction, and increased heart rate Liver: Decreased glucose production Pancreas: Increased insulin secretion, decreased glucagon secretion, B islet cell proliferation GI Tract: Decreased gastric emptying Because these drugs cause weight loss, it is not clear whether the GLP-1 RAs or the weight loss reduces cardiometabolic risks
