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doi: 10.1016/j.neuropharm.2014.09.019 222 ZhangZWangXZhangDLiuYLiL

Dual GLP-1/GIP receptor agonists, such as tirzepatide, potentiate glycemic control, weight reduction, and metabolic improvement through synergistic receptor activation

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(146) observed significant blood-to-brain influx for non-acylated GLP-1 mimetics like exendin-4 and lixisenatide, whereas acylated GLP-1 analogues such as liraglutide and semaglutide showed minimal blood-brain barrier penetration in mice