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[note 16] [175] Toxicity In rodents and primates, sufficiently high doses of amphetamine cause dopaminergic neurotoxicity, or damage to dopamine neurons, which is characterized by dopamine terminal degeneration and reduced transporter and receptor function

However, further studies, that focus on optimizing specific strains to determine appropriate doses and best integrative personalized formulations for individual patients, and also long-term clinical trials that aim to assess and validate the efficacy of these interventions in diverse populations are needed

Although hollow microneedles allow precise and increased nanoparticle delivery through the skin, their complex composition limits this strategy