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Substrate utilization: Impaired mitochondrial function: MMA rises with age even in the absence of documented B12 deficiency, likely reflecting declining mitochondrial function, increased systemic inflammation, and reduced adenosylcobalamin transport efficiency
10.1172/JCI0215595 [DOI] [PMC free article] [PubMed] [Google Scholar] 213.Zinman B, Marso SP, Christiansen E, Calanna S, Rasmussen S, Buse JB, et al
Studies have shown that Rybelsus, when used as part of a comprehensive diabetes management plan, can lead to significant reductions in HbA1c, with some patients achieving levels below the diabetes threshold