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It is suitable for skin with excessive UV exposure, or have dull complexion due to lack of sleep or under long term mental stress, natural dark complexion

In addition, curcumin has been shown in studies to significantly decrease LPO and NO and increase endogenous antioxidant enzyme levels better than pregabalin (a selective Cav2.2 channel antagonist) [121]

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A 2015 permeation study confirmed near-zero transdermal delivery through untreated skin (Li et al., 2015)