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Pre-clinical data in multiple cancer cell lines (including breast, ovarian, pancreatic, colon, non-small cell lung, prostate, thyroid, hepatocellular and oral squamous cell carcinomas and melanoma) have shown the potentiation by HDIs of the effects of topoisomerase I inhibitors (camptothecin, irinotecan, topotecan) topoisomerase II inhibitors (epirubicin, doxorubicin, etoposide, mitoxantrone) and other DNA-damaging agents (cisplatin, oxaliplatin, bleomycin)

Carnitine, on the other hand, is a naturally occurring molecule essential for energy metabolism, particularly in shuttling fatty acids into the mitochondria, and is also known for its antioxidant and cytoprotective properties

It is derived from the intestinal mucosa of pigs and is used in some parts of the world to prevent venous blood clots and treat chronic disorders of the veins