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Constipation is one of several GI side effects linked to GLP-1 receptor agonists, and some research shows that its especially common with semaglutide, the active ingredient in both Ozempic (for Type 2 diabetes) and Wegovy (for weight management)

Liu F, Ma D, Yu J et al (2023b) Overexpression of an ART1-interacting gene OsNAC016 improves Al tolerance in rice

However, there are still some other prospects for new mitochondrial modulation drugs, depending on increasing lipophilic cation moieties, targeting cardiolipin, and aiming on mitochondrial targeting signal peptides (184)

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