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Experimentally resolved GLP-1R complexes with peptide agonists (e.g., GLP-1, exendin-4, and clinically used GLP-1 analogs) commonly exhibit contacts distributed across extracellular regions and the TM bundle similar to those found with neuromedin C, being characterized by cooperative interactions that stabilize active conformations required for G protein coupling (Kawai et al., 2020)

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[1] How Prednisolone May Affect Weight Loss on Wegovy Prednisolone can significantly counteract the weight loss effects of Wegovy through several physiological mechanisms