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It is capable of exerting activities of a putative cytoprotection mediator when native and stable in human gastric juice for more than 24 h [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40] in contrast to conventional peptidergic growth factors

nevertheless, the results, including weight and waist circumference reductions from baseline, provide preliminary evidence of biological activity

The peptide has also been investigated for its effects on macrophage polarization, with studies suggesting it may promote a shift from pro-inflammatory to reparative phenotypes in tissue injury models