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Meta-analyses of more than 4000 participants confirm these reductions are consistent across diabetes types and neuropathy stages [43]

PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)

How Does 5-Amino-1MQ Work in the Body