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We previously emphasized the need for conducting clinical trials that are randomized and placebo-controlled, aimed at investigating the impact of GLP-1 RAs in patients diagnosed with AUD (Fink-Jensen and Vilsbll 2016)

Patients beginning at the standard 2.5 mg dose typically report changes by week 2, while those starting at a lower microdose may not perceive hunger reduction until week 3 or 4

The second part of the strategy was to find the optimal combination of a fatty acid with high albumin affinity, attached to GLP-1 via a water compatible chemical linker, to ensure that the derivatized peptide had high GLP-1R potency in the presence of albumin

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