The results suggest that MB may benefit from chronic cerebral hypoperfusion conditions, such as mild cognitive impairment, vascular dementia, and Alzheimer's
Y2R is widely expressed in multiple brain regions such as the amygdala, hippocampus, cortex, thalamus, lateral septum, olfactory nuclei and striatum (Caberlotto et al., 1998

Oxidants = reactive oxygen species (ROS) / free radicals Antioxidants = molecules that neutralise ROS by donating electrons This is fundamentally a REDOX imbalance Free radicals are electron-deficient molecules that: Steal electrons from healthy cells Trigger chain reactions of oxidation Damage: Cell membranes (lipid peroxidation) Proteins (enzyme dysfunction) DNA (accelerated ageing, impaired repair) In SKIN, this translates to: Fine lines & wrinkles Loss of elasticity Pigmentation irregularities Impaired barrier function Chronic inflammation UV radiation ( primary extrinsic ageing factor ) Pollution & cigarette smoke Inflammation (acne, rosacea, dermatitis) Poor sleep & psychological stress Aggressive aesthetic treatments without adequate antioxidant support Antioxidants donate electrons without becoming unstable themselves, effectively terminating free-radical chain reactions and reducing OXIDATIVE STRESS
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