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Author contributions NL: Validation, Data curation, Methodology, Writing review and editing, Investigation, Writing original draft

Most other GLP-1-naive non-micro users start at 0.5 mg

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Interestingly, tirzepatide, a dual-acting GIP/GLP-1 receptor agonist that is now clinically approved for both obesity and T2D, was designed with an amino acid sequence closely resembling that of native GIP, resulting in strong preference for GIPR binding over the GLP-1R