Their study appeared in Science Translational Medicine
Psychological and neurological triggers including stress, anxiety, and strong emotional responses are potent mast cell activators through neuropeptide pathways, particularly substance P and corticotropin-releasing hormone (CRH)
Subsequently, it was found that blocking EphA receptor signalling using soluble EphA receptors decreases tumor vascular density, tumor volume and cell proliferation [163,164,165]
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