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Patients and physicians have reported severe gastrointestinal complications involving persistent vomiting, severe nausea, abdominal pain, dehydration, malnutrition, and delayed stomach emptying that, in some cases, required hospitalization or emergency room treatment

The trial documented nausea, vomiting, diarrhea, and constipation as the most common adverse events, with incidence peaking during dose escalation and declining at stable doses

The glucagon component is why retatrutide produces greater fat loss, better body composition, more pronounced cardiovascular marker improvements, and more than 80% reduction in liver fat effects that go substantially beyond what appetite suppression alone can explain