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Oral administration of this cocktail, alone or combined with the immune checkpoint inhibitor (ICI) PD-L1, to TAC mice with established tumors, resulted in significantly improved tumor control compared to untreated controls

Moreover, the Nrf2HO1 signaling pathway plays a central role in antioxidative stress, with Nrf2 regulating redox homeostasis by modulating oxidase HO1 expression

DOI: 10.1016/j.ctim.2019.102234

Further CDK11 diversity originates from alternatively spliced isoforms 3 , and from the expression of a shorter CDK11 variant called CDK11 p58 , which arises from translation initiation at a cell-cycle-regulated internal ribosomal entry site 4