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The pharmacodynamic effects of chronic sitagliptin therapy, administered alone or in combination with metformin, were assessed in 16 subjects with type 2 diabetes treated with metformin or sitagliptin, alone or in combination, for 6 weeks (173)

Berberines primary metabolic benefits come through AMPK activation, not sustained GLP-1elevation

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Patients with cirrhosis require ongoing surveillance for hepatocellular carcinoma with ultrasound (with or without alpha-fetoprotein) every six months, regardless of weight loss treatment