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Several key findings emerge from this analysis: Guideline Stability : Metformin retains strong support in clinical guidelines despite therapeutic innovation Complementary Role : Newer agents appear to complement rather than replace Metformin in most clinical scenarios Safety Reassurance : Evolving safety evidence supports broader metformin use than previously recognized Economic Value : Cost-effectiveness remains a compelling argument for Metformins continued use Mechanistic Complexity : Ongoing discovery of metformin mechanisms suggests underappreciated therapeutic potential 10.2 The King Adapts: Evolution vs

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Tataranni PA, Larson DE, Snitker S, Young JB, Flatt JP, Ravussin E

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