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First, although semaglutide's efficacy estimates were derived from the robust STEP 8 trial, long-term extrapolation of weight trajectories and complication risks required assumptions and the application of published risk equations

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Ipamorelin functions as a growth hormone secretagogue, acting specifically on the ghrelin receptor (GHS-R1a) to stimulate the natural release of GH without significantly impacting cortisol or prolactin levels