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(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

However, the greatest number of SCD patients will benefit from improved awareness of SCD as a severe health problem in Africa and India, including the adoption of newborn screening programs and expanded access to even the most fundamental medical care

The basal expression levels of GPX4 and TfR1 do not correlate with the sensitivity to RSL3 among PTC cell lines

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