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Whereas the discussion of pigmented lesions traditionally includes melanoma, we will not provide an explicit section on this topic given the extensive amount of recently published melanoma literature

inhibition of GLS or MYC sensitizes prostate cancer cells to radiotherapy, while autophagy enables glutamine-independent cells to withstand metabolic stress

GSH replenishment in human tissues is difficult due to its shorter half-life, and not easy to penetrate the plasma membrane hence use of prodrugs/precursors such as cysteine, and glycine is the most promising approach 4,45