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Cox-2 expression occurs mainly at the basal urothelial cell level, but its activity can elicit mucosal wounding through excessive recruitment of neutrophils, thereby transforming the colonization landscape in favour of extracellular colonization and growth of the bacteria

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However, a 2024 systematic review in the Journal of Clinical Endocrinology and Metabolism concluded that evidence for inositols benefits remains limited and inconclusive for broader populations beyond PCOS