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Blood work or metabolic screening may be recommended to establish baseline kidney and liver function, which helps determine the safest starting dose and treatment plan

The compounds proposed mechanisms collagen stimulation, wound healing acceleration, anti-inflammatory activity overlap significantly with the physiological goals of physical rehabilitation

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In terms of microbial metabolism, melatonin significantly reduces the relative abundance of the microbiome in the cysteine and methionine metabolism and peptidoglycan biosynthesis pathway in the restraint stress mouse model, while increasing the relative abundance of the microbiome in the tryptophan metabolism, aminobenzoic acid degradation, renin angiotensin system, -aminobutyric acid ergic synapses and type II diabetes pathway (Lin et al., 2021)