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Dietary surveys indicate that usual intake among Americans (4 years of age) is 2.2 mg/day

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Knockout of c-Fos in hepatocytes protects the liver against HCC initiation, while overexpression of c-Fos in the liver accelerates the malignant transformation of HCC, as manifested by necrotic foci, accumulated CD45 + cells, reduced NK and B cells, increased circulating leukocytes, infiltration of immune cells and accumulated lesions in hepatocytes

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