3.1.1 Impact of ROS on cellular function and atherosclerosis Elevated ROS can induce endothelial cell dysfunction or death, disrupting the vascular barrier and leading to vasoconstrictive and vasodilatory dysfunction, vascular smooth muscle cell proliferation and migration, inflammatory responses, and thrombosisprocesses intimately associated with various cardiovascular disorders, including atherosclerosis, hypertension, and CHD (31)
Semaglutide demonstrates substantially greater weight reduction in published trials
Superoxide dismutases (SOD) three forms exist, SOD1 (Intracellular), SOD2/MnSOD (Mitochondrial), SOD3 (Extracellular) Catalase (CAT) Glutathione peroxidase (GPx) In addition to these enzymes, glutathione transferase, ceruloplasmin, hemoxygenase and possibly several other enzymes may participate in enzymatic control of oxygen radicals and their products
24 CPPD prevalence is poorly understood and New Zealand data are not available