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83 Autotaxin inhibits autophagy via the AMPK pathway, thereby disrupting the mucosal barrier and aggravating intestinal inflammation, and AMPK agonists can significantly ameliorate this process, preventing intestinal inflammation and maintaining the integrity of the mucosal barrier

Drinking enough water, eating smaller meals, and avoiding heavy foods may help make the adjustment period easier

In clinical trials, patients achieved an average of 12.4% body weight loss, or 27.3 pounds, over 72 weeks

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