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Nasser Sakran, Department of General Surgery, Holy Family Hospital, Nazareth, Israel, The Azrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel

It's important to discuss stopping tirzepatide with your healthcare provider before making any changes

Drug Development and Industrial Pharmacy 37 (3), 359366 (2011)

These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +