Weight (lbs): Week 0: 270.0 Week 1: 260.6 Week 2: 252.8 Week 3: 246.2 Week 4: 240.0 Week 5: 237.2 Week 6: 233.0 Week 7: missed weigh-in and last injection given Week 8: 227.8 Week 9: 224.6 Week 10: 220.4 Week 11: 217.2 Week 12: 215.0 Total weight loss after 12 weeks: 55 pounds Those are pretty impressive results but they are not entirely a result of the medicine
[For example,] a patient whose main issue is inflammation might benefit more from the anti-inflammatory effect of the drug than a patient whose Crohn's disease has led to strictures, [or] a narrowing of the intestine. The Takeaway GLP-1s decrease inflammation throughout the body, and may improve Crohns disease outcomes
Label expansion: as the label for these GLP1s+ expand, it will naturally extend to already covered disease states (e.g., cardiovascular disease (CVD) for Medicare)
Hepatology 71:722732 Polishchuk EV, Merolla A, Lichtmannegger J, Romano A, Indrieri A, Ilyechova EY et al (2019) Activation of Autophagy, observed in liver tissues from patients with Wilson disease and from ATP7B-Deficient Animals, protects hepatocytes from Copper-Induced apoptosis