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Tirzepatide advantages in trials: Greater total weight loss, stronger HbA1c reduction, favorable body composition changes, long-term durability data Semaglutide advantages in trials: Established cardiovascular outcomes data (SELECT trial), longer real-world track record, oral formulation option Both medications: Require lifestyle changes to maximize results

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GLP-1 dispensing among adolescents, young adults rose from 2020 to 2023 Key takeaways: GLP-1 receptor agonist dispensing increased 659.4% among young women and 587.5% among adolescent girls