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Moreover, rapamycin significantly increased the mRNA expression of forkhead box P3 (Foxp3) both in the ileum and the Peyer's Patches of CMA mice, indicating an increase in Treg cell development (82)

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In vehicle-treated rats, fentanyl elicited (1) an increase in TFL, (2) decreases in pH, pO 2 and sO 2 and increases in pCO 2 (all indicative of ventilatory depression), (3) an increase in Alveolar-arterial gradient (indicative of a mismatch in ventilation-perfusion in the lungs), and (4) changes in ventilatory parameters such as a reduction in tidal volume, that were indicative of pronounced ventilatory depression