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Sperm cryopreservation is the best pre-treatment for future fertility, as in the case of patients anticipating suppression of spermatogenesis

By targeting key cellular mechanisms, including oxidative stress, calcium influx, and membrane phospholipid asymmetry, these agents offer potential therapeutic uses for disorders associated with excessive erythrocyte death, such as hemolytic anemias, CKD, and metabolic syndromes

Recent research has found that mutations in the TCA cycle enzymes SDH, FH, and IDH resulted in a dysfunction of the TCA cycle and defects in mitochondrial metabolism in a wide range of human cancers [7, 8]

These provide the most objective assessment of both efficacy and side effect burden