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Transcranial magnetic and direct current stimulation in the treatment of depression: Basic mechanisms and challenges of two commonly used brain stimulation methods in interventional psychiatry

PRP also restores damaged connective tissue by promoting the migration, proliferation and activation of fibroblasts.[15,16] Platelets also host a vast reservoir of over 800 proteins which when secreted act upon SCs, fibroblasts, osteoblasts and endothelial and epithelial cells.[12] The main purpose of using PRP for therapeutics originated from the idea to deliver the growth factors, cytokines and -granules to the site of injury, which acts as cell cycle regulators, and promote healing process across variety of tissues.[8] The PRP preparations are known to contain many growth factors, chemokines and cytokines [Figure 1] which induce the downstream signaling pathways that ultimately lead to synthesis of proteins necessary for collagen, osteoid and extracellular matrix formation.[17] PRP also has numerous cell adhesion molecules including fibrin, fibronectin, vitronectin and thrombospondin that trigger the assimilation of osteoblasts, fibroblasts and epithelial cells