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Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans
(TNF-, IL-6, TGF-), (IL-10)
9.2 GSH-triggered drug release and prodrug activation strategies GSH-responsive drug delivery and prodrug activation systems often exploit its high affinity for metal ions to trigger selective drug release within the tumor microenvironment (TME)
Although a fairly large proportion of patients have reported a number of side effects, particularly at the gastrointestinal level (nausea, vomiting, diarrhoea), these side effects tend to diminish over time and adherence to treatment remains high, with about 5% of patients discontinuing treatment due to side effects
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