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5.3 Combination therapies 5.3.1 Low-dose IL-2 It is well-established that IL-2 plays a pivotal role in T cell development, demonstrating a preferential capacity to promote the expansion and functional specialization of Treg, Th1, Th2, and Th9 cells, while it does not directly support the differentiation of Th17 and T follicular helper (Tfh) cells (261, 262)