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Studies have shown that PCC patients with symptoms lasting more than 30 days exhibit persistent SARS-CoV-2-specific T cells and heightened antibody affinity, strongly suggesting the continued presence of viral antigens ( 3.2 Central transmission of peripheral inflammation and the self-sustaining nature of neuroinflammation Peripheral inflammation is characterized not only by elevated levels of pro-inflammatory cytokines (IL-6, TNF-, IL-1) in the circulatory (123, 124), but its pathological effects are also transmitted to the central nervous system via both humoral and neural pathways, thereby converting peripheral events into a potentially sustained central pathological state

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Structural basis for the interaction of TAK1 kinase with its activating protein TAB1