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Species differences in metabolism, receptor expression, and pharmacokinetics mean that effective doses in rats do not predict safe or effective doses in humans

FIGURE 4 To confirm the results at the cellular level, we also detected the phosphorylation levels of Akt and GSK-3 in the back skin of each group (Figure 5A), as well as the translational expression of -Catenin and Wnt10b (Figure 5B)