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Sources Sources last verified July 16, 2026 FDA Wegovy Prescribing Information, revised February 2026Supports: Injectable semaglutide elimination half-life of approximately 1 week

She also notes that it layers well with skincare and makeup, so its a great option for those who regularly apply multiple topicals or wear complexion products daily

Overall, GLP-1RAs may become a useful component of integrated obesity-directed KOA care, but they should be regarded as part of a proposed framework rather than as validated disease-modifying therapy

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