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Studies have found that inhibiting KGDD activity due to mutations in IDH1/2, FH, or SDH increases sensitivity to DNA damaging agents, and the mechanisms described are due to changes in methylation (Inoue et al., 2016

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Cytoskeletal Dynamics TB-500 is frequently examined for its relationship with actin organization, while combination studies may investigate broader structural responses

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This is the first time the two drugs were compared head-to-head, which makes the findings a little more robust, Dr

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45th Lunar and Planetary Science Conference (2014)

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