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De la dcouverte des hormones incrtines aux doubles et triples agonistes GIP / GLP-1 / glucagon From the discovery of incretin hormones to GIP / GLP-1 / glucagon double and triple agonists 1 Service de diabtologie, CHU Piti-Salptrire, Paris, France 2 Universit Paris-Diderot, Unit de biologie fonctionnelle et adaptative / CNRS UMR 8251, Paris, France * Rsum Lide de traiter les diabtes sucrs par des hormones intestinales a t propose ds les dbuts de lendocrinologie, en 1902, mais ne sera mise en pratique quau dbut des annes 2000