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Aunque los estudios de seguridad cardiovascular no tenan poder para detectar diferencias en los componentes individuales del MACE, se vieron algunas diferencias entre los estudios en estos componentes individuales

NSAIDs primarily reduce inflammation by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for the production of prostaglandins, which are involved in the inflammatory response, including the promotion of pain, fever, and tissue damage

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Despite the recommendations, there is widespread use of these drugs by patients who do not meet these criteria