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Somatostatin release also occurred in the dorsal dentate gyrus in rats subjected to immobilization (Arancibia et al., 2 mRNA was upregulated following acute exposure of rats to a potential predator (Nanda et al., 2008), a finding recently also observed in the medial habenula following chronic mild stress (Faron-Gorecka et al., 2016)

For these assays, increased levels of cAMP were measured as an increase of the 485/535 nm FRET ratio serving as a readout for binding of cAMP to the H188 biosensor that is based on the exchange protein activated by cAMP 15

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Their anti-inflammatory properties also suggest benefits for chronic inflammatory conditions such as inflammatory bowel disease (IBD), with some clinical observations noting improvements in IBD symptoms