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A systemic side effect, like nausea, happens because of how the medication interacts with your hormones and digestion

If they can maintain the smaller meal sizes and activity levels they adopted while on the drug, the weight can be sustained, he said

The excessive accumulation of abdominal adipose tissue represents a major risk factor for metabolic syndrome, cardiovascular disease, type 2 diabetes mellitus (T2DM), certain malignancies, hepatic steatosis, and cerebrovascular accidents

Food cravings often intensify because GLP-1 receptor activation is declining, allowing your stomach to empty faster and your appetite hormones (like ghrelin) to rise