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Mitophagy, in particular, serves as a key mechanism for maintaining metabolic homeostasis by selectively removing damaged mitochondria and limiting the accumulation of ROS [47].In CRC, the PINK1Parkin-mediated mitophagy pathway and Drp1-driven mitochondrial fission have been shown to act in concert to preserve mitochondrial quality under chemotherapeutic stress [48]

By doing so, it helps prevent the accumulation of these toxins, which can have negative effects on the skin and overall health

Furthermore, abnormal expression of certain iron metabolism-related genes was confirmed in the epidermis of PV cases, among which Cyb561d2 was found to promote ferrous iron overload and lipid peroxidation accumulation in HaCaT cells [209]

Effect of a Topical Collagen Tripeptide on Antiaging and Inhibition of Glycation of the Skin: A Pilot Study