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Importantly, the proteomic similarity of Day 30 iHLOs to PHHs, with a 33.46% expression difference from liver tissue, underscores their physiological relevance compared to traditional models like HepG2 cells, which exhibit a 54.36% protein difference from liver tissue, or HepaRG cells, with a 45.40% protein difference

[3] That reversibility is a crucial, often-omitted caveat: tesamorelins effect is a maintained pharmacological state, not a one-time fix. We discuss the visceral-fat data and its limits further in our reference on tesamorelins visceral-fat effects and safety profile