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Cardiac, liver, and brain tissues were immediately excised and rapidly frozen in dry ice to preserve their integrity

N Engl J Med 2021;385: 896-907

Impact of glucagon-like peptide-1 receptor agonists on adiponectin concentrations: A meta-analysis of randomized controlled trials

In the simulation of F347, the ligand adopts the same orientation as in the crystal structure, whereas the orientation of the ligand in the simulation of C347 is varied during the simulation process (the trifluoromethyl-pyrazole group in particular)