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Collectively, these convergent actions maintain genome integrity, preserve proteostasis, suppress inflammation, and attenuate cellular senescence, illustrating how GLP-1 RAs restore systemic homeostasis to promote healthy aging

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n , Protein-free or SLC33A1-containing liposomes were preloaded with buffer alone (no substrate), 10 mM unlabelled acetyl-CoA, or 10 mM unlabelled GSSG, and incubated with 20 M [ 3 H]GSSG for 40 min