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Xu, Y., Buikema, H., van Gilst, W

Systemic inhibition of ferroptosis raises legitimate concerns about potential side effects, particularly the suppression of anti-tumor immunity, given the role of ferroptosis in immune surveillance

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No PT-141s MC1R binding affinity is 50-fold lower than its MC4R affinity, meaning the dose required to produce melanogenesis would far exceed the dose that causes intolerable MC4R-mediated side effects like nausea and blood pressure elevation